Free shipping on all orders over $ 500

STF-083010

Cat. No. M8331
STF-083010 Structure
Size Price Availability Quantity
5mg USD 65  USD65 In stock
10mg USD 87  USD87 In stock
50mg USD 300  USD300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. STF-083010 inhibits IRE1 endonuclease and mRNA splicing activity in response to endopasmic reticulum (ER) stress, but has no affect on the kinase activity of IRE1.

Product Citations
Chemical Information
Molecular Weight 317.38
Formula C15H11NO3S2
CAS Number 307543-71-1
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wenwen Chien, et al. Oncotarget. Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells

[2] Ioanna Papandreou, et al. Blood. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

Related IRE1 Products
Z4P

Z4P is a BBB-permeable IRE1 inhibitor (IC50: 1.11 μM).

IRE1α kinase-IN-9

IRE1α kinase-IN-9 is a potent IRE-1α inhibitor, exhibits an average IC50 value of <0.1 μM.

IRE1α kinase-IN-8

IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, is a potent IRE-1α inhibitor.

Kira8 Hydrochloride

Kira8 Hydrochloride (AMG-18 Hydrochloride) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.

KIRA-7 

KIRA-7, an imidazopyrazine compound, binds the IRE1α kinase (IC50 of 110 nM) to allosterically inhibit its RNase activity. KIRA-7 has an anti-fibrotic effect.

  Catalog
Abmole Inhibitor Catalog




Keywords: STF-083010 supplier, IRE1, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.