| Cat.No. | Name | Information |
|---|---|---|
| M2198 | Curcumin | Curcumin (Diferuloyl), a natural phenolic compound, is a p300/CREB binding protein specific inhibitor that inhibits histone/non-histone acetylation and histone acetyltransferase-dependent chromatin transcription. Curcumin inhibited NF-κ B and MAPKs, and had anti-inflammatory, antioxidant, anti-proliferation and anti-angiogenesis effects. Curcumin induces Nrf2 protein stabilization through Keap1 cysteine modification. |
| M3645 | MG149 | MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM). |
| M3797 | Remodelin | Remodelin is a novel, potent Acetyl-transferase NAT 10 inhibitor that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization. |
| M2482 | C646 | C646 is a selective inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. C646 preferentially selective for p300 versus other acetyltransferases. |
| M45238 | AU-18069 | AU-18069 is a CBP/p300 HAT inhibitor that can be used in studies related to hematological and solid tumors. |
| M41678 | KAT modulator-1 | KAT modulator-1 is a KAT modulator. |
| M41677 | KAT6-IN-1 | KAT6-IN-1 is a potent KAT6 inhibitor. |
| M41676 | MC4171 | MC4171 is a selective KAT8 inhibitor (IC50=8.1 µM). |
| M41675 | MOZ-IN-3 | MOZ-IN-3 is a KAT6A (MOZ) acetyltransferase inhibitor (IC50: 30 nM). |
| M41674 | Ep300/CREBBP-IN-4 | Ep300/CREBBP-IN-4 is a potent Ep300 and CREBBP inhibitor with IC50s of 0.024 and 0.064 μM, respectively. |
| M41673 | Ep300/CREBBP-IN-3 | Ep300/CREBBP-IN-3 is a potent Ep300 and CREBBP inhibitor with IC50s of 0.056 and 0.095 μM, respectively. |
| M41672 | Ep300/CREBBP-IN-2 | Ep300/CREBBP-IN-2 is a potent and orally active Ep300 and CREBBP inhibitor with IC50s of 0.052 and 0.148 μM, respectively. |
| M41671 | Ep300/CREBBP-IN-8 | Ep300/CREBBP-IN-8 is a potent and orally active Ep300 and CREBBP inhibitor with IC50s of 0.014 and 0.018 μM, respectively. |
| M30926 | Naphthol AS-E | Naphthol AS-E is a potent and cell-permeable inhibitor of KIX-KID interaction. Naphthol AS-E directly binds to the KIX domain of CBP (Kd:8.6 µM), blocks the interaction between the KIX domain and the KID domain of CREB with IC50 of 2.26 µM. Naphthol AS-E can be used for cancer research. |
| M30335 | DCH36_06 | DCH36_06 is a potent and selective p300/CBP inhibitor with IC50s of 0.6 μM and 3.2 μM for p300 and CBP, respectively. DCH36_06 mediated p300/CBP inhibition leading to hypoacetylation on H3K18 in leukemic cells. Anti-tumor activity. |
| M29580 | SYY-B085-1 | SYY-B085-1 is a histone acetyltransferase (HAT) inhibitor extracted from patent WO2019201291A1. |
| M29245 | TH1834 dihydrochloride | TH1834 dihydrochloride is a specific Tip60 (KAT5) histone acetyltransferase inhibitor. TH1834 dihydrochloride induces apoptosis and increases DNA damage in breast cancer. TH1834 dihydrochloride does not affect the activity of related histone acetyltransferase MOF. Anticancer activity. |
| M28805 | PU141 | PU141 is a selected pyridoisothiazolone HAT inhibitor. PU141 is selective toward CBP and p300. PU141 induces cellular histone hypoacetylation and inhibits growth of several neoplastic cell lines originating from different tissues. Anticancer activity. |
| M21260 | CPI-1612 | CPI-1612 is a tool compound that appears to be a fairly efficient EP300/CBP histone acetyltransferase (HAT) inhibitor, exhibiting activity in xenograft models with good PK of higher species. |
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