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MG149

Cat. No. M3645
MG149 Structure
Size Price Availability
2mg USD 100 Out of stock
5mg USD 150 Out of stock
10mg USD 240 Out of stock
50mg USD 720 Out of stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

MG149 is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM). MG 149, at 200 μM, inhibites about 90% of Tip60 activity but has no inhibitory impact on p300 and PCAF. MG 149 is essentially competitive with Ac-CoA and noncompetitive with the histone substrate. MG149 inhibits acetyltransferase activity of nuclear extract from tissue samples from different brain regions in mice. MG149 inhibits the p53 and the NF-κB pathways.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 340.46
Formula C22H28O3
CAS Number 1243583-85-8
Purity >99%
Solubility DMSO
Storage at -20°C
References

Basic nuclear processes affected by histone acetyltransferases and histone deacetylase inhibitors.
Legartová S, et al. Epigenomics. 2013 Aug;5(4):379-96. PMID: 23895652.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: MG149 supplier, Histone Acetyltransferase, inhibitors

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