Inhibitor/Activator
| Cat.No. | Name | Information |
|---|---|---|
| M28369 | TC-G 1005 | TC-G 1005 is a potent, selective and orally active agonist of the BA receptor Takeda G protein-coupled receptor 5 (TGR5), with EC50s of 0.72 and 6.2 nM for hTGR5 and mTGR5, respectively. TC-G 1005 can reduce glucose levels in vivo. |
| M28272 | Firuglipel | Firuglipel (DS-8500a) is an orally available, potent and selective GPR119 agonist. |
| M28122 | LY2881835 | LY2881835 is a potent and selective agonist of G protein-coupled receptor 40 (GPR40). LY2881835 has efficacious and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion. LY2881835 has the potential for the research of type 2 diabetes mellitus. |
| M28079 | AMG 837 calcium hydrate | AMG 837 calcium hydrate is a potent, orally bioavailable and partial agonist of GPR40/FFA1. AMG 837 calcium hydrate inhibits specific [3H]AMG 837 binding at the human FFA1 receptor with a pIC50 of 8.13. AMG 837 calcium hydrate could enhance insulin secretion and lower glucose levels in rodents. |
| M28051 | Fezagepras sodium | Fezagepras (Setogepram) sodium acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Fezagepras sodium decreases renal, liver and pancreatic fibrosis. Fezagepras sodium exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions. |
| M28005 | GPR120 Agonist 2 | GPR120 Agonist 2 is a GPR120 agonist extracted from patent US 20110313003 A1, example 209. |
| M27673 | GSK2041706A | GSK2041706A (GSK706) is a potent G protein-coupled receptor 119 (GPR119) agonist. GSK2041706A can be used for the research of type 2 diabetes. |
| M27599 | Fezagepras | Fezagepras (Setogepram) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Fezagepras decreases renal, liver and pancreatic fibrosis. Fezagepras exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions. |
| M25489 | 2-Oleoylglycerol | 2-Oleoylglycerol is a GPR119 agonist, with an EC50 of 2.5 μM for human GPR119 in transiently transfected COS-7 cells. 2-Oleoylglycerol stimulates glucagon-like peptide-1 (GLP-1) secretion in vivo. |
| M22486 | AH-7614 | AH-7614 is a potent and selective FFA4 (GPR120) antagonist, with pIC50s of 7.1, 8.1, and 8.1 for human, mouse, and rat FFA4, respectively. AH-7614 has selectivity for FFA4 over FFA1 (pIC50<4.6). |
| M21826 | AM-1638 | AM-1638 is a potent and orally bioavailable GPR40/FFA1 full agonist with an EC50 of 0.16 μM. |
| M20180 | WAY-388798 | WAY-388798 is a agonist of free fatty acid receptor 1 (GPR40) |
| M6468 | AS 2034178 | AS 2034178 is a selective FFA1 (GPR40) agonist. |
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