| Cat.No. | Name | Information |
|---|---|---|
| M7325 | Rimonabant Hydrochloride | Rimonabant hydrochloride is a cannabinoid receptor antagonist, which binds selectively to central cannabinoid receptors (CB1) with high affinity |
| M30812 | S-777469 | S-777469 is a selective and orally available cannabinoid type 2 receptor (CB2) agonist with a Ki of 36 nM. S-777469 significantly suppresses compound 48/80-induced scratching behavior in mice in a dose-dependent manner. S-777469 produces its antipruritic effects by inhibiting itch signal transmission through CB2 agonism. |
| M30475 | Linoleoyl ethanolamide | Linoleoyl ethanolamide (Linoleic acid monoethanolamide) is classified as a fatty acid ethanolamide. Linoleoyl ethanolamide only weakly binds G-protein-coupled cannabinoid receptors of type-1（CB1）and CB2 receptors, and inhibits the binding of [3H]CP-55,940 with Kis of 10 and 25 μM, respectively. Linoleoyl ethanolamide is 4-fold less potent than anandamide at causing catalepsy in mice and it does not prolong sleep time. |
| M30392 | KM-233 | KM-233 is a classical cannabinoid with good blood brain barrier penetration. KM-233 possesses a selective affinity for the CB2 receptors relative to THC. KM-233 is effective at reducing U87 glioma tumor burden, and can be used for glioma research. |
| M30287 | RTICBM-189 | RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the addictive agent-seeking behavior in rats. |
| M30173 | NESS 0327 | NESS 0327 is a cannabinoid antagonist with high selectivity for the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor. |
| M30122 | Ibipinabant | Ibipinabant (SLV319) is a potent, selective and orally active antagonist of cannabinoid CB1 receptor, with a Ki of 7.8 nM. Ibipinabant shows more than 1000-fold selectivity for CB1 over CB2 (Ki=7943 nM). Ibipinabant can be used for the research of obesity and diabetic. |
| M29983 | Drinabant | Drinabant (AVE1625) is an orally active CB1 receptor antagonist. Drinabant (AVE1625) inhibits the agonist-stimulated calcium signal with IC50 values of 25 nM and 10 nM for the hCB1-R and rCB1-R, respectively, and is ineffective for the hCB2-R. |
| M29263 | BAY 38-7271 | BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist, with Kis of 1.85 nM and 5.96 nM for recombinant human CB1 receptor and CB2 receptor, respectively. BAY 38-7271 has strong neuroprotective properties. |
| M29091 | ZCZ011 | ZCZ011 is a potent and brain penetrant cannabinoid 1 (CB1) receptor positive allosteric modulator. ZCZ011 potentiates binding of CP55,940 to the CB1 receptor, enhances anandamide (AEA)-stimulated GTPγS binding in mouse brain membranes. ZCZ011 increases β-arrestin recruitment and ERK phosphorylation in hCB1 cells. ZCZ011 can be used for researching neuropathic and inflammatory pain. |
| M28462 | Leelamine | Leelamine is a weak agonist of cannabinoid receptors CB1 and CB2. Leelamine also inhibits pyruvate dehydrogenase kinases (PDKs). Leelamine exhibits anti-tumor activity. |
| M28030 | AM-6538 | AM6538 is a long-acting, high affinity and pseudo-irreversible cannabinoid (CB) antagonist. AM6538 is a structural analog of rimonabant. AM6538 can be effectively used to evaluate the apparent efficacy of cannabinoid full and partial agonists. AM6538 may be useful in future studies that require temporary reductions in cannabinoid receptor availability. |
| M27713 | COR170 | COR170 (11u) is a selective CB2 inverse-agonist which is a 4-quinolone-3-carboxylic acid derivative with a Ki value of 3.8 nM for CB2 receptor. COR170 can be used for the research of inflammation and neuroprotection. |
| M24918 | Nimacimab | Nimacimab (RYI-018) is a negative-allosteric modulating monoclonal antibody targeting CB1 receptor. Nimacimab can be used for research of metabolic diseases. |
| M13918 | Synaptamide | Synaptamide (Dehydroepiandrosteron; DHEA) is an endogenous metabolite and structural analogue of Anandamide. |
| M11426 | AM404 | AM404 is an endocannabinoid reuptake inhibitor that can block anandamide transport with IC50 values in the low mole range. The isolated rat hepatic artery was constricted by norepinephrine and relaxed by AM404. PEC50 value was 7.4 (corresponding EC50 value was 0.04 µM). It has neuroprotective effects. |
| M10789 | AZD1940 | AZD1940 is an orally active, high-affinity CB1/CB2 receptor agonist for CB1R and CB2R pKi the values are 7.93 and 9.06, respectively, and can be used in studies that relieve pain. |
| M8674 | AM4113 | AM4113 is a Cannabinoid CB-1 neutral antagonist. |
| M8321 | PF-514273 | PF-514273 is a highly selective CB1 antagonist. |
| M7071 | O-2050 | O-2050 is a putative CB1 silent antagonist; displays mixed activity at CB receptors. |
| M6430 | AM 6545 | AM 6545 is a high affinity and selective CB 1 antagonist. |
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