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  Catalog
Abmole Inhibitor Catalog 2017

Aurora Kinase Aurora Kinase

Inhibitors

Cat.No.  Name Information
M3701 SNS-314 SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively.
M3555 GSK1070916 GSK1070916 is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM. It displays >100-fold selectivity against the closely related Aurora A-TPX2 complex.
M3552 PHA-680632 PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively. It has 10- to 200-fold higher IC50 for FGFR1, FLT3, LCK, PLK1, STLK2, and VEGFR2/3.
M3516 MK-5108 MK-5108 (VX-689) is a highly selective Aurora A inhibitor with IC50 of 0.064 nM and is 220- and 190-fold more selective for Aurora A than Aurora B/C, while it inhibits TrkA with less than 100-fold selectivity.
M3221 PF-03814735 PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1.
M2856 MK-8745 MK-8745 is a potent and selective Aurora A inhibitor with IC50 of 0.6 nM, more than 450-fold selectivity for Aurora A over Aurora B.
M2364 ABT-348 ABT-348 is a novel ATP-competitive inhibitor of Aurora B, Aurora C and Aurora A with IC50 of 7 nM, 1 nM and 120 nM, respectively.
M2339 SCH 1473759 SCH 1473759 is a novel sub-nanomolar Aurora A/B inhibitor with IC50 of 4 nM and 13 nM, respectively.
M2188 Reversine Reversine is a novel small molecule ATP-competitive Aurora kinase inhibitor with IC50 of 98.5 nM for Aurora B.
M2169 AMG 900 AMG 900 is a potent and selective, orally available small molecule aurora kinase inhibitor.
M2154 TAK-901 TAK-901 is a novel small-molecule inhibitor of Aurora A and Aurora B with IC50 of 21 nM and 15 nM.
M2127 Hesperadin Hesperadin is an ATP-competitive inhibitor of Aurora B kinase with IC50 of 250 nM.
M2103 CCT137690 CCT137690 is a potent inhibitor of Aurora kinases with IC50 values of 15, 19 and 25 nM at Aurora A, Aurora C and Aurora B respectively.
M1881 Tozasertib Tozasertib (VX-680, MK-0457) is a potent and selective pan-Aurora kinase inhibitor active against all Bcr/Abl proteins.
M1877 ZM447439 ZM447439 is the first Aurora family kinase inhibitor with IC50 of 50 nM for Aurora B kinase.
M1769 PHA-739358 PHA-739358 (Danusertib) is a small molecule with low nanomolar activity against all aurora kinases (AKs) with IC50 value of 13 nM for aurora-A and 79 nM for aurora-B respectively.
M1752 MLN8237 MLN8237 (Alisertib) is a second-generation, orally bioavailable, highly selective Aurora kinase A inhibitor with IC50 of 61 nM.
M1751 MLN8054 MLN8054 is an orally bioavailable, highly selective small molecule inhibitor of Aurora with IC50s of 0.004uM and 0.172uM. for Aurora A and Aurora B.
M1706 ENMD-2076 ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor.
M1694 CYC116 CYC116 is a potent, small molecule inhibitor of Aurora A, B and C with IC50 value of 44, 19 and 65 nM respectively.
M1691 CCT-129202 CCT129202 is an Aurora kinase inhibitor with IC50 of 0.042 ± 0.022, 0.198 ± 0.05, and 0.227 ± 0.064 μmol/L for Aurora A, Aurora B, and Aurora C, respectively.
M1663 AZD1152-HQPA AZD1152-HQPA (Barasertib) is a highly potent and selective inhibitor of Aurora with Ki values of 0.36 and 1369 nM for Aurora B and Aurora A respectively.
M1655 AT9283 AT9283 is a potent inhibitor of several protein kinases, including Aurora A, Aurora B, Janus kinase 2 (JAK2), JAK3, and ABL.


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