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Aurora Kinase Aurora Kinase

Cat.No.  Name Information
M1881 Tozasertib Tozasertib (VX-680, MK-0457) is a potent and selective pan-Aurora kinase inhibitor active against all Bcr/Abl proteins.
M1752 MLN8237 (Alisertib) MLN8237 (Alisertib) is a second-generation, orally bioavailable, highly selective Aurora kinase A inhibitor with IC50 of 61 nM.
M1663 AZD1152-HQPA AZD1152-HQPA (Barasertib) is a highly potent and selective inhibitor of Aurora with Ki values of 0.36 and 1369 nM for Aurora B and Aurora A respectively.
M1877 ZM447439 ZM447439 is the first Aurora family kinase inhibitor with IC50 of 50 nM for Aurora B kinase.
M1769 PHA-739358 (Danusertib) PHA-739358 (Danusertib) is a small molecule with low nanomolar activity against all aurora kinases (AKs) with IC50 value of 13 nM for aurora-A and 79 nM for aurora-B respectively.
M1751 MLN8054 MLN8054 is an orally bioavailable, highly selective small molecule inhibitor of Aurora with IC50s of 0.004uM and 0.172uM. for Aurora A and Aurora B.
M1706 ENMD-2076 ENMD-2076 is an orally-active, Aurora A/angiogenic kinase inhibitor.
M1694 CYC116 CYC116 is a potent, small molecule inhibitor of Aurora A, B and C with IC50 value of 44, 19 and 65 nM respectively.
M1691 CCT-129202 CCT129202 is an Aurora kinase inhibitor with IC50 of 0.042 ± 0.022, 0.198 ± 0.05, and 0.227 ± 0.064 μmol/L for Aurora A, Aurora B, and Aurora C, respectively.
M1655 AT9283 AT9283 is a potent inhibitor of several protein kinases, including Aurora A, Aurora B, Janus kinase 2 (JAK2), JAK3, and ABL.
M41412 Aurora Kinases-IN-4 Aurora Kinases-IN-4 is a covalent and ATP competitive aurora kinase A inhibitor (IC50: 1.7 nM).
M38914 Derrone Derrone, a prenylated isoflavones, is an Aurora kinase inhibitor, with IC50 values of 6 and 22.3 μM against Aurora B and Aurora A, respectively. Derrone shows anti-tumor activity.
M31003 CD532 hydrochloride  CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer.
M29927 Aurora kinase inhibitor-2  Aurora kinase inhibitor-2 is a selective and ATP-competitive Aurora kinase inhibitor with IC50s of 310 nM and 240 nM for Aurora A and Aurora B, respectively.
M29436 AAPK-25  AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM.
M29284 Aurora kinase inhibitor-8  Aurora kinase inhibitor-8 is a highly selective inhibitor of the Aurora kinases.
M28750 CD532  CD532 is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 also can directly interact with AURKA and induces a global conformational shift. CD532 can be used for the research of cancer.
M28425 AKI603  AKI603 is an inhibitor of Aurora kinase A (AurA), with an IC50 of 12.3 nM. AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation. AKI603 exhibits strong anti-proliferative activity in leukemic cells.
M27784 SCH-1473759 hydrochloride  SCH-1473759 hydrochloride is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.
M20733 SP-96 SP-146 is a potent, selective and non-ATP-competitive inhibitor of Aurora B with IC50 of 0.316 nM. SP-146 can be used for the research of triple negative breast cancer (TNBC).
M20284 WAY-661516 WAY-661516 is a Aurora kinase A inhibitor.
M20251 WAY-638641 WAY-638641 is a Aurora kinase A inhibitor.
M20247 WAY-636982 WAY-636982 is a Aurora kinase A inhibitor.




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