About 8 results found for searched term "GSK-503" (0.065 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M4804 | GSK-503 | Histone Methyltransferase |
| GSK-503 is a potent EZH2 inhibitor with potential anticancer activity. | ||
| M5325 | GSK 650394 | SGK |
| GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2, respectively. | ||
| M10049 | GSK2795039 | NADPH Oxidase |
| GSK-2795039 | ||
| GSK2795039 is the first small molecule NADPH oxidase 2 (NOX2) inhibitor, with a mean pIC50 of 6 in different cell-free assays. | ||
| M10528 | GSK3685032 | DNA Methyltransferase |
| GSK3685032 is a potent first-in-class DNMT1-selective inhibitor. | ||
| M10824 | GSK2245035 | TLR |
| GSK2245035 is a highly potent, selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential stimulation of interferon type 1 (IFN). GSK2245035 for IFNα and TNFα pEC50 9.3 and 6.5, respectively. GSK2245035 effectively inhibits allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 has the potential for asthma. | ||
| M28047 | GSK-5503A | Calcium Channel |
| GSK-5503A is a calcium-release activated calcium (CRAC) channel blocker. GSK-5503A effectively inhibits stromal interaction molecule 1 (STIM1) mediated Orai1 and Orai3 currents in vitro. GSK-5503A can be used for the research of asthma and allergic disorders. | ||
| M45092 | (R)-GSK-3685032 | DNA Methyltransferase |
| (R)-GSK-3685032 is the R-isomer of GSK-3685032.GSK-3685032 is a non-time-dependent, non-covalent, first-in-class, reversible selective inhibitor of DNMT1 with an IC50 value of 0.036 μM.GSK-3685032 induces DNA GSK-3685032 induces loss of DNA methylation, transcriptional activation and cancer cell growth inhibition. | ||
| M45093 | (S)-GSK-3685032 | DNA Methyltransferase |
| (S)-GSK-3685032 is the inactive isomer of GSK-3685032.GSK-3685032 is a non-time-dependent, non-covalent, first-in-class, reversible selective inhibitor of DNMT1 with an IC50 value of 0.036 μM.GSK-3685032 induces DNA GSK-3685032 induces loss of DNA methylation, transcriptional activation and cancer cell growth inhibition. | ||
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