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(Z)-Aconitic acid

Cat. No. M11218
(Z)-Aconitic acid Structure
Synonym:

1,2,3-PROPENETRICARBOXYLIC ACID

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25mg USD 95  USD95 In stock
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Biological Activity

(Z)-Aconitic acid (cis-Aconitic acid) is a cis isomer of Aconitic acid. (Z)-Aconitic acid (cis-Aconitic acid) is an intermediate product of the isomerization of citrate into isocicirate in the tricarboxylic acid cycle.

Chemical Information
Molecular Weight 174.11
Formula C6H6O6
CAS Number 585-84-2
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Billy T Tchegnitegni, et al. Z Naturforsch C J Biosci. A dihydrochalcone derivative and further steroidal saponins from Sansevieria trifasciata Prain

[2] Qing Huang, et al. Yao Xue Xue Bao. [Metabonomic profiling of plasma metabolites in Wistar rats to study the effect of aging by means of GC/TOFMS-based techniques]

[3] Chul-Sa Kim, et al. Z Naturforsch C J Biosci. Antifeedants of Indian barnyard millet, Echinochloa frumentacea link, against brown planthopper, Nilaparvata lugens (Stål)

[4] Bernd Schwarz, et al. J Agric Food Chem. Isolation, structure determination, and sensory activity of mouth-drying and astringent nitrogen-containing phytochemicals isolated from red currants (Ribes rubrum)

[5] I Ruhl, et al. Z Lebensm Unters Forsch. [Organic acids in vegetables. I. Brassica, leaf and bulb vegetables as well as carrots and celery]

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Keywords: (Z)-Aconitic acid, 1,2,3-PROPENETRICARBOXYLIC ACID supplier, Metabolite/Endogenous Metabolite, inhibitors, activators

 
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