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Yuheinoside

Cat. No. M16875
Yuheinoside Structure
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Biological Activity

Yuheinoside

Chemical Information
CAS Number 72396-01-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Aziz Mohammat, et al. Molecules. Rapid Quantification and Quantitation of Alkaloids in Xinjiang Fritillaria by Ultra Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry

[2] Bao-Qin Lin, et al. Planta Med. Inhibitors of acetylcholine esterase in vitro--screening of steroidal alkaloids from Fritillaria species

[3] Ping Li, et al. Yao Xue Xue Bao. Simultaneous determination of the major isosteroidal alkaloids and their glucosides in the bulbs of Fritillaria by high performance liquid chromatography coupled with evaporative light scattering detection

[4] Y J Xu, et al. Yao Xue Xue Bao. [Isolation and identification of yibeinoside B]

[5] D M Xu, et al. Yao Xue Xue Bao. [Isolation and identification of yibeinoside A]

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