Yoda1 is an agonist of the mechanotransduction channel Piezo1. Yoda1 acts by eliciting Ca2+ flux in Piezo1- but not vector-transfected cells.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO ≥ 25 mg/mL|
Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation.
Dela Paz NG, et al. Biochem Biophys Res Commun. 2018 Feb 26;497(1):220-225. PMID: 29428723.
Chemical activation of the mechanotransduction channel Piezo1.
Syeda R, et al. Elife. 2015 May 22;4. PMID: 26001275.
Heparan sulfate is a complex and linear polysaccharide, which expressed abundantly on the cell surface and in the extracellular matrix.
Dextran (Dextran 40) has an inhibitory effect on thrombocyte aggregation.
|Protein kinase inhibitors 1
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.
VBIT-12 is a potent inhibitor of VDAC1, directly interacting with purified VDAC1 and reducing its channel conductance.
|NADP disodium salt
NADP disodium salt is a participant coenzyme in aerobic and anaerobic oxidations.
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