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Cat. No. M9372
Yoda1 Structure

GlyT2-IN-1; Yoda 1

Size Price Availability Quantity
5mg USD 107 In stock
10mg USD 144 In stock
50mg USD 576 In stock
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Quality Control
Biological Activity

Yoda1 is an agonist of the mechanotransduction channel Piezo1. Yoda1 acts by eliciting Ca2+ flux in Piezo1- but not vector-transfected cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 355.27
Formula C13H8Cl2N4S2
CAS Number 448947-81-7
Purity 100.00%
Solubility DMSO ≥ 25 mg/mL
Storage at -20°C

Yoda1-induced phosphorylation of Akt and ERK1/2 does not require Piezo1 activation.
Dela Paz NG, et al. Biochem Biophys Res Commun. 2018 Feb 26;497(1):220-225. PMID: 29428723.

Chemical activation of the mechanotransduction channel Piezo1.
Syeda R, et al. Elife. 2015 May 22;4. PMID: 26001275.

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Keywords: Yoda1, GlyT2-IN-1; Yoda 1 supplier, inhibitors

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