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Xanthyletin

Cat. No. M16302
Xanthyletin Structure
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Biological Activity

Xanthyletin

Chemical Information
CAS Number 553-19-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kittiya Wittayapipath, et al. Sci Rep. Evaluation of antifungal effect and toxicity of xanthyletin and two bacterial metabolites against Thai isolates of Pythium insidiosum

[2] Kittiya Wittayapipath, et al. BMC Microbiol. Analysis of xanthyletin and secondary metabolites from Pseudomonas stutzeri ST1302 and Klebsiella pneumoniae ST2501 against Pythium insidiosum

[3] Xin-Yu Li, et al. J Asian Nat Prod Res. A new xanthyletin-type coumarin from the roots of Peucedanum praeruptorum

[4] Cristiane de Melo Cazal, et al. J Chromatogr A. Isolation of xanthyletin, an inhibitor of ants' symbiotic fungus, by high-speed counter-current chromatography

[5] P Magiatis, et al. J Nat Prod. Synthesis and cytotoxic activity of pyranocoumarins of the seselin and xanthyletin series

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