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Wilfortrine

Cat. No. M6227
Wilfortrine Structure
Size Price Availability Quantity
5mg USD 1100 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Wilfortrine has several pharmacological effects, including an inhibitory effect on liver cancer cell proliferation. However, whether wilfortrine can induce liver cancer cell apoptosis has not been elucidated. We investigated the role of wilfortrine on liver cancer cell HepG2 apoptosis and analyzed its possible mechanisms to provide a theoretical basis for clinical analysis of liver cancer pathogenesis. Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell cycle, mainly by promoting Bax expression and inhibiting anti-apoptotic protein Bcl-2 expression.

Protocol
Cell Experiment
Cell lines HepG2 cells
Preparation method The HepG2 liver cancer cell line was maintained in DMEM supplemented with 10% FBS and 100 U/mL penicillin-streptomycin in a humid atmosphere containing 5% CO2 at 37°C. Wilfortrine (40 mM) was used to treat HepG2 liver cancer cells for 48 h.
Concentrations 40 mM
Incubation time 48 h
Animal Experiment
Animal models
Formulation
Dosages
Administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 873.81
Formula C41H47NO20
CAS Number 37239-48-8
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Effect of Combined Treatment Using Wilfortrine and Paclitaxel in Liver Cancer and Related Mechanism.
Li S, et al. Med Sci Monit. 2016 Apr 4;22:1109-14. PMID: 27043783.

Effect of wilfortrine on human hepatic cancer HepG2 cell proliferation potential in vitro.
Yue M, et al. Genet Mol Res. 2015 Nov 30;14(4):15349-55. PMID: 26634500.

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