Vitamin K2 (Menaquinone-4) is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
| Molecular Weight | 444.65 |
| Formula | C31H40O2 |
| CAS Number | 863-61-6 |
| Form | Solid |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage | 4°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Jun Iwamoto, et al. Curr Pharm Des. Retracted Note: Effects of Vitamin K2 on Osteoporosis
[2] Toshiro Sato, et al. Nutrients. MK-7 and Its Effects on Bone Quality and Strength
[3] Jun Iwamoto. Nutrients. Vitamin K₂ therapy for postmenopausal osteoporosis
| Related Metabolite/Endogenous Metabolite Products |
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| Ursocholic acid
Ursocholic acid is a bile acid found predominantly in bile of mammals, which can be transformed into deoxycholic acid by the intestinal microflora in mice. |
| 5β-Cholanic acid
5β-Cholanic acid can be used for 5β-Cholanic acid derivatives synthesis. |
| D-Thyroxine
D-Thyroxine is a thyroid hormone that can inhibit TSH secretion. D-Thyroxine can be used for the research of hypercholesterolemia. |
| Allolithocholic acid
Allolithocholic acid is a steroid acid could found in normal serum and feces. Allolithocholic acid facilitates excretion, absorption, and transport of fats and sterols in the intestine and liver. |
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