Vancomycin is a glycopeptide antibiotic as well as a macrocyclic compound that can be used to construct models of bronchiectasis combined with lung infections, as well as for studies related to various bacterial infectious conditions.
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Vancomycin purchased from AbMole
| Molecular Weight | 1449.25 |
| Formula | C66H75Cl2N9O24 |
| CAS Number | 1404-90-6 |
| Solubility (25°C) | DMSO ≥ 15 mg/mL |
| Storage | 2-8°C, dry, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Alaina N Burns, et al. A Moving Target-Vancomycin Therapeutic Monitoring
[3] Donald P Levine. Vancomycin: a history
[4] Michael J Rybak. The pharmacokinetic and pharmacodynamic properties of vancomycin
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