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Vancomycin

Cat. No. M9334
Vancomycin Structure
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Biological Activity

Vancomycin is an antibiotic for the treatment of bacterial infections. It has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 1449.25
Formula C66H75Cl2N9O24
CAS Number 1404-90-6
Purity
Solubility DMSO ≥ 15 mg/mL
Storage 2-8°C, dry, protect from light, sealed
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Vancomycin supplier, Anti-infection, inhibitors

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