N-Carbamoyl-DL-aspartic acid (USA) is a pyrimidine biosynthesis intermediate that can be taken up by Saccharomyces cerevisiae when proline is the only nitrogen source, but USA uptake is inhibited when ammonium sulfate or glutamate is the nitrogen source.
Molecular Weight | 176.13 |
Formula | C5H8N2O5 |
CAS Number | 923-37-5 |
Form | Solid |
Storage | 2-8°C, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] William H Bowen. Odontology. The Stephan Curve revisited
[5] Jayasree Seayad, et al. Org Biomol Chem. Asymmetric organocatalysis
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