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URB597

Cat. No. M3404
URB597 Structure
Synonym:

KDS-4103

Size Price Availability Quantity
25mg USD 160 In stock
100mg USD 480 In stock
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Quality Control
Biological Activity

URB597 is a relatively selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 4.6 and 0.5 nM in brain membranes and intact neurons, respectively. FAAH is the primary degradatory enzyme for the endocannabinoid anandamide and, as such, inhibition of FAAH leads to an accumulation of anandamide in the CNS and periphery where it activates cannabinoid receptors. URB597 ?produced measurable antidepressant and analgesic effects by increasing endocannabinoids. URB597 ?shows both anti-nociceptive and anxiolytic effects in vivo but not evokes other symptoms associated with cannabinoid-like compounds. Hence, URB597 may provide a new strategy for the treatment of pain and anxiety.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Adult male Wistar rats (250–300 g) and C57/BL6 or FAAH-/- mice
Formulation sterile 0.9% sodium chloride solution
Dosages 0.3 mg/kg
Administration Inject subcutaneously in a single dose 2 hours or 16 hours before killing
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 338.4
Formula C20H22N2O3
CAS Number 546141-08-6
Purity 100.00%
Solubility DMSO 60 mg/mL
Storage at -20°C
Related FAAH Products
FAAH-IN-2

FAAH-IN-2 is a potent FAAH(fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2.

PF-3845

PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.

JNJ-1661010

JNJ-1661010 is a potent and selective FAAH inhibitor with IC50 of 10 nM (rat) and 12 nM (human), exhibits >100-fold selectivity for FAAH-1 when compared to FAAH-2.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: URB597, KDS-4103 supplier, FAAH, inhibitors

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