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Cat. No. M3404
URB597 Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
25mg USD 160 In stock
100mg USD 480 In stock
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Quality Control
Biological Activity

URB597 is a relatively selective fatty acid amide hydrolase (FAAH) inhibitor with IC50 of 4.6 and 0.5 nM in brain membranes and intact neurons, respectively. FAAH is the primary degradatory enzyme for the endocannabinoid anandamide and, as such, inhibition of FAAH leads to an accumulation of anandamide in the CNS and periphery where it activates cannabinoid receptors. URB597 ?produced measurable antidepressant and analgesic effects by increasing endocannabinoids. URB597 ?shows both anti-nociceptive and anxiolytic effects in vivo but not evokes other symptoms associated with cannabinoid-like compounds. Hence, URB597 may provide a new strategy for the treatment of pain and anxiety.

Customer Product Validations & Biological Datas
Source Cell Physiol Biochem (2018). Figure 1. URB597
Method injections
Cell Lines WKY rats
Concentrations 1mg/kg
Incubation Time two weeks
Results Interestingly, chronic URB597 administration significantly increased intramyocardial glycogen level in the DOCA-salt rats compared to the hypertensive group alone
Cell Experiment
Cell lines
Preparation method
Incubation time
Animal Experiment
Animal models Adult male Wistar rats (250–300 g) and C57/BL6 or FAAH-/- mice
Formulation sterile 0.9% sodium chloride solution
Dosages 0.3 mg/kg
Administration Inject subcutaneously in a single dose 2 hours or 16 hours before killing
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 338.4
Formula C20H22N2O3
CAS Number 546141-08-6
Purity 100.00%
Solubility DMSO 60 mg/mL
Storage at -20°C
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Abmole Inhibitor Catalog 2017

Keywords: URB597, KDS-4103 supplier, FAAH, inhibitors

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