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Tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II) dichloride is an oxygen-sensitive fluorescence indicator widely used as a probe for luminescence detection and oxygen quantification. The maximum absorption wavelength is max 455 nm and the maximum luminescence is λmax 613 nm.
| Molecular Weight | 1169.17 |
| Formula | C72H48Cl2N6Ru |
| CAS Number | 36309-88-3 |
| Solubility (25°C) | DMSO ：25mg/ml |
| Storage | 2-8℃, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Ruipeng Xue, et al. Mater Sci Eng C Mater Biol Appl. Rapid response oxygen-sensing nanofibers
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