Triiodothyronine (Liothyronine) is a potent agonist of both thyroid hormone receptors TRα and Trβ with Kis of 2.3 nM for both. Triiodothyronine (0.01-0.1 μM) results in a decrease in the TRalpha1:TRalpha2 mRNA ratio in HepG2 cells.
This product is soluble but easy to precipitate after freezing in DMSO. NaOH is recommended as a stock solution.
| Molecular Weight | 650.97 |
| Formula | C15H12I3NO4 |
| CAS Number | 6893-02-3 |
| Solubility (25°C) | 1M NaOH : 50 mg/mL (ultrasonic and warming and heat to 60°C) DMSO 40 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Thyroid Hormone Receptor Products |
|---|
| ZYT-1
ZYT-1 is a thyroid receptor (THR-β) agonist. |
| VK-0214
VK-0214 is an orally active, selective small molecule agonist of the thyroid receptor (THR-β) for studies related to X-linked adrenoleukodystrophy (X-ALD) and hyperlipidemia. |
| PF-00277343
PF-00277343 is a selective thyroid receptor (THR-β) agonist. |
| Parathyroid Hormone (1-34), bovine
Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. |
| (D-Trp12, Tyr34)-pTH (7-34) amide (bovine)
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) is a potent and competitive antagonist of parathyroid hormone (PTH), with a Ki of 69 nM in bovine renal cortical membrane. |
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