Triiodothyronine is a potent agonist of both thyroid hormone receptors TRα and Trβ with Kis of 2.3 nM for both. Triiodothyronine (0.01-0.1 μM) results in a decrease in the TRalpha1:TRalpha2 mRNA ratio in HepG2 cells.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 6 mg/mL|
Triiodothyronine affects the alternative splicing of thyroid hormone receptor alpha mRNA.
Timmer DC, et al. J Endocrinol. 2003 Nov;179(2):217-25. PMID: 14596673.
Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha.
Macchia PE, et al. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):349-54. PMID: 11120878.
Photochlor is a lipophilic, second-generation, chlorin-based photosensitizer.
AMPPD is a new biochemistry ultrasensitive alkaline phosphatase substrate.
DM1-SMCC is DM1 with a reactive linker SMCC, which can react with antibody to make ADC.
Mitapivat is a potent human R-type pyruvate kinase (PKR) inhibitor.
VH-298 is a potent VHL inhibitor that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, with a Kd value of 80 to 90 nM.
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