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Triiodothyronine

Cat. No. M6079
Triiodothyronine Structure
Size Price Availability Quantity
100mg USD 50 In stock
200mg USD 80 In stock
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Quality Control
Biological Activity

Triiodothyronine is a potent agonist of both thyroid hormone receptors TRα and Trβ with Kis of 2.3 nM for both. Triiodothyronine (0.01-0.1 μM) results in a decrease in the TRalpha1:TRalpha2 mRNA ratio in HepG2 cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 650.97
Formula C15H12I3NO4
CAS Number 6893-02-3
Purity >99%
Solubility DMSO 6 mg/mL
Storage at -20°C
References

Triiodothyronine affects the alternative splicing of thyroid hormone receptor alpha mRNA.
Timmer DC, et al. J Endocrinol. 2003 Nov;179(2):217-25. PMID: 14596673.

Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha.
Macchia PE, et al. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):349-54. PMID: 11120878.

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  Catalog
Abmole Inhibitor Catalog 2017




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