Trigonelline, an alkaloid with potential antidiabetic activity, is an efficient Nrf2 inhibitor capable of blocking Nrf2-dependent proteasome activity and thereby apoptosis protection in pancreatic cancer cells. Treatment of cells with Trigonelline attenuates H2O2 induced cell deaths and improves the antioxidant activity. In addition, Trigonelline regulates the apoptotic gene caspase-3, caspase-9 and anti-apoptotic gene Bcl-2, Bcl-XL during H2O2 induced oxidative stress in H9c2 cells.
Molecular Weight | 137.14 |
Formula | C7H7NO2 |
CAS Number | 535-83-1 |
Solubility (25°C) | DMSO 6 mg/mL (May need ultrasonic) |
Storage | 4°C, protect from light |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Minji Choi, et al. Phytother Res. Trigonelline induces browning in 3T3-L1 white adipocytes
[4] Iziar A Ludwig, et al. Food Funct. Coffee: biochemistry and potential impact on health
Related Metabolite/Endogenous Metabolite Products |
---|
Ursocholic acid
Ursocholic acid is a bile acid found predominantly in bile of mammals, which can be transformed into deoxycholic acid by the intestinal microflora in mice. |
5β-Cholanic acid
5β-Cholanic acid can be used for 5β-Cholanic acid derivatives synthesis. |
D-Thyroxine
D-Thyroxine is a thyroid hormone that can inhibit TSH secretion. D-Thyroxine can be used for the research of hypercholesterolemia. |
Allolithocholic acid
Allolithocholic acid is a steroid acid could found in normal serum and feces. Allolithocholic acid facilitates excretion, absorption, and transport of fats and sterols in the intestine and liver. |
Biliverdin
Biliverdin is the product of the oxidation of bilirubin. Biliverdin can be synthesized via a non-protoporphyrin pathway in Corynebacterium glutamicum. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.