Free shipping on all orders over $ 500

Trelagliptin

Cat. No. M2341

Trelagliptin Structure

Synonym: SYR-472

Size Price Availability Quantity
5mg USD 165 In stock
10mg USD 270 In stock
50mg USD 860 In stock
100mg USD 1380 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Trelagliptin (SYR-472) is a highly selective once-weekly oral dipeptidyl peptidase-4 (DPP-4) inhibitor for type 2 diabetes. Trelagliptin (SYR-472) treatment produced clinically and statistically significant improvements in glycaemic control in patients with type 2 diabetes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 357.38
Formula C18H20FN5O2
CAS Number 865759-25-7
Purity >99%
Solubility DMSO 60 mg/mL
Storage at -20°C
References

SYR-472, a novel once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor, in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial.
Inagaki N, et al. Lancet Diabetes Endocrinol. 2014 Feb;2(2):125-32. PMID: 24622716.

Related DPP-4 Products
Teneligliptin HCl

Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

Teneligliptin

Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

Sitagliptin

Sitagliptin(MK 0431) is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts.

Saxagliptin hydrate

Saxagliptin H2O is a selective and reversible DPP4 inhibitor with IC50 of 26 nM.

Anagliptin

Anagliptin is a potent and selective DPP-4 inhibitor(IC50= 3.8 nM); > 10 fold less potent for DPP-8 and DPP-9.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Trelagliptin, SYR-472 supplier, DPP-4, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.