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Trelagliptin

Cat. No. M2341
Trelagliptin Structure
Synonym:

SYR-472

Size Price Availability Quantity
10mM*1mL In DMSO USD 85 In stock
5mg USD 80 In stock
10mg USD 120 In stock
50mg USD 480 In stock
100mg USD 800 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Trelagliptin (SYR-472) is a highly selective once-weekly oral dipeptidyl peptidase-4 (DPP-4) inhibitor for type 2 diabetes. Trelagliptin (SYR-472) treatment produced clinically and statistically significant improvements in glycaemic control in patients with type 2 diabetes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 357.38
Formula C18H20FN5O2
CAS Number 865759-25-7
Purity >98%
Solubility DMSO 60 mg/mL
Storage at -20°C
References

SYR-472, a novel once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor, in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial.
Inagaki N, et al. Lancet Diabetes Endocrinol. 2014 Feb;2(2):125-32. PMID: 24622716.

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Teneligliptin HBr

Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

Teneligliptin

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Sitagliptin

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Saxagliptin hydrate

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Trelagliptin, SYR-472 supplier, DPP-4, inhibitors

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