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Tranylcypromine hemisulfate

Cat. No. M9090
Tranylcypromine hemisulfate Structure
Synonym:

Tranylcypromine sulfate; Tranylcypromine

Size Price Availability Quantity
100mg USD 80 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tranylcypromine hemisulfate is an irreversible, nonselective MAO inhibitor. Tranylcypromine is used as an antidepressant and anxiolytic agent in the clinical treatment of mood and anxiety disorders, respectively. Tranylcypromine (100 μM) significantly protects RGCs from glutamate neurotoxicity-induced apoptosis as well as apoptosis induced by oxidative stress. Tranylcypromine promotes mitogen-activated protein kinase 12 (p38 MAPKγ) expression under conditions of glutamate (Glu)-induced stress.

Tranylcypromine (500 mM) injection exerts neuroprotective effects within intracellular apoptotic signaling pathways and suppresses morphologic changes in the retina of the rat, suppresses caspase 3 activity and recovers p38 MAPKγ expression in the retina after NMDA-induced injury, and enhances RGC survival after retinal injury via the attenuation of NMDA neurotoxicity. Tranylcypromine (10 µg/g) causes an approximate and significant doubling of labeled cells in the combined brain regions examined, as detected by BrdU immunohistochemistry.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 364.46
Formula C18H24N2O4S
CAS Number 13492-01-8
Purity >98%
Solubility Water: ≥ 30 mg/mL (Need ultrasonic)
Storage at -20°C
References

Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity.
Tsutsumi T, et al. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6461-6473. PMID: 27893888.

Tranylcypromine, a lysine-specific demethylase 1 (LSD1) inhibitor, suppresses lesion growth and improves generalized hyperalgesia in mouse with induced endometriosis.
Sun Q, et al. Reprod Biol Endocrinol. 2016 Apr 9;14:17. PMID: 27062244.

Neuroprotective effects of the monoamine oxidase inhibitor tranylcypromine and its amide derivatives against Aβ(1-42)-induced toxicity.
Caraci F, et al. Eur J Pharmacol. 2015 Oct 5;764:256-63. PMID: 26162702.

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  Catalog
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Keywords: Tranylcypromine hemisulfate, Tranylcypromine sulfate; Tranylcypromine supplier, Monoamine Oxidase, inhibitors

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