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trans-Cinnamaldehyde

Cat. No. M14413
trans-Cinnamaldehyde Structure
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200mg USD 48  USD48 In stock
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Quality Control & Documentation
Biological Activity

trans-Cinnamaldehyde can be used to prepare highly polyfunctionalized furan ring by reaction of alkyl isocyanides with dialkyl acetylenedicarboxylate. trans-Cinnamaldehyde can be used to synthesize trans-cinnamaldehyde -β-cyclodextrin complex, an antimicrobial edible coating that increases the shelf life of fresh-cut fruits.

Chemical Information
Molecular Weight 132.16
Formula C9H8O
CAS Number 14371-10-9
Solubility (25°C) DMSO 90 mg/mL
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Islam A A Ali, et al. Trans-Cinnamaldehyde Attenuates Enterococcus faecalis Virulence and Inhibits Biofilm Formation

[2] Shu Wang, et al. Trans-Cinnamaldehyde Exhibits Synergy with Conventional Antibiotic against Methicillin-Resistant Staphylococcus aureus

[3] Xiaobin Luo, et al. Trans-Cinnamaldehyde Increases Random Pattern Flap Survival Through Activation of the Nitric Oxide Pathway

[4] Amanda A Doyle, et al. A review of cinnamaldehyde and its derivatives as antibacterial agents

[5] Ruyuan Zhu, et al. Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety

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