Toluidine Blue O is a basic thiazine metachromatic dye with high affinity for acidic tissue components. Toluidine Blue has wide applications in vital staining in living tissues and a special stain.
| Molecular Weight | 305.83 |
| Formula | C15H16ClN3S |
| CAS Number | 92-31-9 |
| Solubility (25°C) | DMSO 10 mg/mL (ultrasonic and warming) Soluble in water |
| Storage | RT, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Alper Keten, et al. Am J Emerg Med. Toluidine blue
[4] G P Wysocki. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Toluidine blue--viewpoints
[5] H Ephros, et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. Toluidine blue--viewpoints
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