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Thioflavine S

Cat. No. M13803
Thioflavine S Structure
Synonym:

Thioflavin S; Direct Yellow 7

Size Price Availability Quantity
100mg USD 60  USD60 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Thioflavine S is a fluorescent histochemical marker of dense core senile plaques.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number 1326-12-1
Purity >99%
Solubility Water ≥ 50 mg/mL
Storage 2-8°C, protect from light
References

[1] Shawn M Barton, et al. Molecules. Inhalable Thioflavin S for the Detection of Amyloid Beta Deposits in the Retina

[2] Xing Ze Wang, et al. Analyst. Driving force to detect Alzheimer's disease biomarkers: application of a thioflavine [email protected] ratiometric fluorescent sensor for smart detection of presenilin 1, amyloid β-protein and acetylcholine

[3] Matthew Biancalana, et al. Biochim Biophys Acta. Molecular mechanism of Thioflavin-T binding to amyloid fibrils

[4] D Larry Sparks. J Mol Neurosci. Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer's-like amyloid beta in rabbit brain

[5] R Guntern, et al. Experientia. An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease

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Keywords: Thioflavine S, Thioflavin S; Direct Yellow 7 supplier, Fluorescent Dye, inhibitors

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