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Thiamine chloride

Cat. No. M6112
Thiamine chloride Structure
Synonym:

Vitamin B1

Size Price Availability Quantity
50mg USD 110 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Thiamine (vitamin B1) was the first vitamin discovered, leading to the concept of vitamins. Thiamine chloride —the biologically active form of vitamin B1—is vital for all cellular life because it is a co-factor for several essential enzymes.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models weaning male Wistar rats
Formulation
Dosages 4.2 mg/kg
Administration oral
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 300.81
Formula C12H17ClN4OS
CAS Number 59-43-8
Purity >99%
Solubility 50 mg/mL in water
Storage at -20°C
References

Alternatives to vitamin B1 uptake revealed with discovery of riboswitches in multiple marine eukaryotic lineages.
McRose D, et al. ISME J. 2014 Dec;8(12):2517-29. PMID: 25171333.

The body vitamin B1 levels of rats fed a diet containing the minimum requirement of vitamin B1 is reduced by exercise.
Shibata K, et al. J Nutr Sci Vitaminol (Tokyo). 2013;59(2):87-92. PMID: 23727637.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Thiamine chloride, Vitamin B1 supplier, inhibitors

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