Thalidomide-O-amido-C4-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker.
| Molecular Weight | 516.42 |
| Formula | C21H23F3N4O8 |
| CAS Number | 1799711-25-3 |
| Solubility (25°C) | DMSO 32 mg/mL (May need ultrasonic) |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related E3 Ligase Ligand-Linker Conjugates Products |
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| Cereblon inhibitor 2
Cereblon inhibitor 2 is a Cereblon inhibitor useful in solid tumor research, especially breast cancer. |
| Pomalidomide-C7-NH2 hydrochloride
Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) hydrochloride is an E3 ligase ligand-linker conjugate. |
| Thalidomide-NH-PEG2-C2-NH-Boc
Thalidomide-NH-PEG2-C2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a PEG linker used for dBRD9 synthesis. dBRD9 is a selective BRD9 probe PROTAC degrader for the study of BAF complex biology. |
| Thalidomide-C2-amido-C2-COOH
Thalidomide-C2-amido-C2-COOH incorporates a CRBN ligand for the E3 ubiquitin ligase, and a linker. Thalidomide-C2-amido-C2-COOH can be used to design PROTAC CDK2/9 Degrader-1. |
| Pomalidomide-PEG4-C-COOH
Pomalidomide-PEG4-C-COOH (E3 Ligase Ligand-Linker Conjugates 1) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker. |
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