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Tetramethylrhodamine ethyl ester perchlorate (TMRE) is a mitochondria specific dye (λex=549 nm, λem=575 nm).
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 514.95 |
| Formula | C26H27ClN2O7 |
| CAS Number | 115532-52-0 |
| Purity | >98% |
| Solubility | DMSO ≥ 100 mg/mL |
| Storage | 2-8°C, protect from light, dry, sealed |
Measuring Mitochondrial Transmembrane Potential by TMRE Staining
Lisa C Crowley, et al. Cold Spring Harb Protoc. 2016 Dec 1;2016(12). PMID: 27934682.
Confocal laser scanning microscopy imaging of dynamic TMRE movement in the mitochondria of epithelial and superficial cortical fiber cells of bovine lenses
Vladimir Bantseev, et al. Mol Vis. 2005 Jul 14;11:518-23. PMID: 16052167.
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