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Tetramethylrhodamine ethyl ester perchlorate

Cat. No. M9743
Tetramethylrhodamine ethyl ester perchlorate Structure
Synonym:

TMRE

Size Price Availability Quantity
10mg USD 80 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tetramethylrhodamine ethyl ester perchlorate (TMRE) is a mitochondria specific dye (λex=549 nm, λem=575 nm).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 514.95
Formula C26H27ClN2O7
CAS Number 115532-52-0
Purity >98%
Solubility DMSO ≥ 100 mg/mL
Storage 2-8°C, protect from light, dry, sealed
References

Measuring Mitochondrial Transmembrane Potential by TMRE Staining
Lisa C Crowley, et al. Cold Spring Harb Protoc. 2016 Dec 1;2016(12). PMID: 27934682.

Confocal laser scanning microscopy imaging of dynamic TMRE movement in the mitochondria of epithelial and superficial cortical fiber cells of bovine lenses
Vladimir Bantseev, et al. Mol Vis. 2005 Jul 14;11:518-23. PMID: 16052167.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tetramethylrhodamine ethyl ester perchlorate, TMRE supplier, Fluorescent Dye, inhibitors

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