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Teneligliptin

Cat. No. M5994

Teneligliptin   Structure
Size Price Availability Quantity
50mg USD 160 In stock
100mg USD 250 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Teneligliptin is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 426.58
Formula C22H30N6OS
CAS Number 760937-92-6
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Teneligliptin in management of type 2 diabetes mellitus.
Sharma SK, et al. Diabetes Metab Syndr Obes. 2016 Aug 16;9:251-60. PMID: 27574456.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Teneligliptin supplier, DPP-4, inhibitors

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