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Teduglutide

Cat. No. M10249
Teduglutide Structure
Synonym:

ALX 0600

Size Price Availability Quantity
1mg USD 300  USD300 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Teduglutide is a glucagon-like peptide-2 (GLP- 2) receptor agonist used for the treatment of short-bowel syndrome. Teduglutide has similar binding affinity, agonist potency, and agonist efficacy as GLP-2 in assays with the rat GLP-2 receptor. Administration of teduglutide to rats gave a significant increase in small intestine weight and an increase in the height of intestinal villi.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 3752.08
Formula C164H252N44O55S
CAS Number 197922-42-2
Purity >98%
Solubility
Storage -20°C, sealed
References

[1] Beatrice E Rosete, et al. Expert Rev Gastroenterol Hepatol. Teduglutide for pediatric short bowel syndrome patients

[2] No authors listed. Aust Prescr. Teduglutide for short bowel syndrome

[3] Samuel A Kocoshis, et al. JPEN J Parenter Enteral Nutr. Safety and Efficacy of Teduglutide in Pediatric Patients With Intestinal Failure due to Short Bowel Syndrome: A 24-Week, Phase III Study

[4] Palle B Jeppesen, et al. Gastroenterology. Factors Associated With Response to Teduglutide in Patients With Short-Bowel Syndrome and Intestinal Failure

[5] Palle B Jeppesen, et al. Gastroenterology. Teduglutide reduces need for parenteral support among patients with short bowel syndrome with intestinal failure

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Keywords: Teduglutide, ALX 0600 supplier, Glucagon Receptor, inhibitors

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