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TC-S 7006

Cat. No. M7391

All AbMole products are for research use only, cannot be used for human consumption.

TC-S 7006 Structure

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Quality Control & Documentation
Biological Activity

TC-S 7006 is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 50 nM). Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. Inhibits LPS-induced TNF-α secretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferation in vitro. Also reduces cytolytic activity of human CD8+ cytotoxic T lymphocytes. Cell permeable.

Chemical Information
Molecular Weight 404.83
Formula C21H14ClFN6
CAS Number 871307-18-5
Solubility (25°C) DMSO 40.48 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Hishikawa, et al. J Cardiovasc Pharmacol. Tranilast restores cytokine-induced nitric oxide production against platelet derived growth factor in vascular smooth muscle cells.

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  Catalog
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Keywords: TC-S 7006 supplier, MAPKAPK2/MAP3K/MAP4K, inhibitors, activators

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