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TC-E 5003

Cat. No. M7365
TC-E 5003 Structure
Synonym:

TCE5003

Size Price Availability Quantity
5mg USD 155  USD155 In stock
10mg USD 270  USD270 In stock
25mg USD 480  USD480 In stock
50mg USD 740  USD740 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tc-e 5003 is a selective inhibitor of PRMT1 with an IC50 of 1.5 µM against hPRMT1. Tc-e 5003 has anti-inflammatory properties in TLR4 signal transduction.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 401.26
Formula C16H14Cl2N2O4S
CAS Number 17328-16-4
Purity >98%
Solubility DMSO 20 mg/mL
Storage at -20°C
References

[1] Rowley, et al. J Med Chem. 5-(4-Chlorophenyl)-4-methyl-3-(1-(2-phenylethyl)piperidin-4-yl)isoxazole: a potent, selective antagonist at human cloned dopamine D4 receptors.

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Keywords: TC-E 5003, TCE5003 supplier, PRMTs, inhibitors

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