Survodutide (BI 456906) acetate is an glucagon and glucagon-like peptide 1 (GLP-1) receptor agonist Survodutide (TFA) is equivalent to Survodutide.
| CAS Number | 2805997-46-8 (free base) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Chaoyang Li et al. Prev Chronic Dis. Global Surveillance of trans-Fatty Acids
| Related Glucagon Receptor Products |
|---|
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| Exendin-3/4 (59-86)
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| HAEGTFTSDVS
HAEGTFTSDVS is the first N-terminal 1-11 residues of GLP-1 peptide. |
| GLP-1(32-36)amide
GLP-1(32-36)amide, a pentapeptide, derived from the C terminus of the glucoregulatory hormone GLP-1. |
| HAEGTFTSD
HAEGTFTSD is a 9-residue peptide of human GLP-1 peptide or GLP-1(7-36), amide. |
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