Spinosyn is a neuroprotective C-glycoside flavonoid isolated from the seeds of Zizyphus jujube. Spinosyn inhibits the production and polymerization of Aβ1-42 by activating the Nrf2/HO-1 pathway.
Molecular Weight | 608.54 |
Formula | C28H32O15 |
CAS Number | 72063-39-9 |
Form | Solid |
Solubility (25°C) | DMSO ≥ 200 mg/mL |
Storage | 4°C, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Biao Zhang, et al. Synthesis and identification of artificial antigen of spinosin
Related Amyloid Products |
---|
Methyl tridecanoate
Methyl tridecanoate inhibits β-amyloid aggregation. Methyl tridecanoate weakly inhibits acetylcholinesterase (AChE). |
Trontinemab
Trontinemab is a bispecific human IgG1-κ antibody that targets amyloid β A4 precursor protein (APP) and transferrin receptor (TFRC).Trontinemab may be used in Alzheimer's disease-related studies. |
RAGE antagonist peptide
RAGE antagonist peptide is an advanced glycation end products (RAGE) antagonist. |
Fmoc-Ala-Glu-Asn-Lys-NH2
Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. |
β-Amyloid peptide(16-20)
β-Amyloid peptide(16-20) is a amino acid sequences (KLVFF) of Amyloid-β (Abeta). |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.