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SGI-7079

Cat. No. M2180
SGI-7079 Structure
Size Price Availability Quantity
5mg USD 95 In stock
10mg USD 150 In stock
50mg USD 560 In stock
100mg USD 730 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SGI-7079 is a novel Axl inhibitor. SGI-7079 decreased IBC cell proliferation, migration and invasion in vitro and inhibited tumor growth of IBC cells in vivo. Mesenchymal cells also expressed increased levels of the receptor tyrosine kinase Axl and showed a trend toward greater sensitivity to the Axl inhibitor SGI-7079, whereas the combination of SGI-7079 with erlotinib reversed erlotinib resistance in mesenchymal lines expressing Axl and in a xenograft model of mesenchymal NSCLC.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 455.53
Formula C26H26FN7
CAS Number 1239875-86-5
Purity >99%
Solubility 91 mg/mL in DMSO
Storage at -20°C
References

TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase.
Wang X, et al. Cancer Res. 2013 Sep 6. PMID: 24014597.

An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance.
Byers LA, et al. Clin Cancer Res. 2013 Jan 1;19(1):279-90. PMID: 23091115.

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  Catalog
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Keywords: SGI-7079 supplier, Axl, inhibitors

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