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SCH 900776

Cat. No. M1996
SCH 900776 Structure
Synonym:

SCH900776

Size Price Availability Quantity
10mg USD 225 In stock
50mg USD 580 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SCH 900776 is a novel and more selective Chk1 inhibitor that potently inhibits Chk1 and abrogates cell-cycle arrest induced by SN38. Checkpoint kinase 1 (CHK1) is an essential serine/threonine kinase that responds to DNA damage and stalled DNA replication. SCH 900776 reduced the growth-inhibitory concentration of hydroxyurea by 20- to 70-fold. Additionally, SCH 900776 suppresses accumulation of the Chk1 pS296 autophosphorylation in a dose-dependent manner. SCH 900776 exposure phenocopies short interfering RNA-mediated CHK1 ablation and interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce dsDNA breaks and cell death in tumor cell backgrounds. SCH 900776 is currently in phase I clinical trials.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 376.25
Formula C15H18BrN7
CAS Number 891494-63-6
Purity >99%
Solubility DMSO 60 mg/mL
Storage at -20°C
References

Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites.
Montano R, et al. Mol Cancer Ther. 2012 Feb;11(2):427-38. PMID: 22203733.

Targeting the replication checkpoint using SCH 900776, a potent and functionally selective CHK1 inhibitor identified via high content screening.
Guzi TJ, et al. Mol Cancer Ther. 2011 Apr;10(4):591-602. PMID: 21321066.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SCH 900776, SCH900776 supplier, Checkpoint, inhibitors

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