Free shipping on all orders over $ 500

SBI-0640756

Cat. No. M9260
SBI-0640756 Structure
Synonym:

SBI-756

Size Price Availability Quantity
2mg USD 98 In stock
5mg USD 175 In stock
10mg USD 300 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. SBI-0640756 impaired the eIF4F complex assembly independently of mTOR and attenuated growth of BRAF-resistant and BRAF-independent melanomas. SBI-0640756 (SBI-756) inhibits the growth of NRAS, BRAF, and NF1-mutant melanomas in vitro. 

In vivo, SBI-0640756 (SBI-756) delays the onset and reduces the incidence of Nras/Ink4a melanomas.

Protocol
Cell Experiment
Cell lines Melanoma lines
Preparation method Melanoma lines are plated (triplicates 384-well plates; 1,500 cells per well) and cell viability is assessed 48 hours after treatment with indicated compounds. Growth inhibition is calculated as percentage of DMSO-treated controls and is plotted against the log drug concentration.
Concentrations 1, 2, 5 μmol/L
Incubation time 48 h
Animal Experiment
Animal models
Formulation
Dosages
Administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 404.82
Formula C23H14ClFN2O2
CAS Number 1821280-29-8
Purity >98%
Solubility DMSO: ≥ 60 mg/mL
Storage at -20°C
References

SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex.
Feng Y, et al. Cancer Res. 2015 Dec 15;75(24):5211-8. PMID: 26603897.

Related Products
Chymostatin

Chymostatin is a chymotryptase-like serine proteases inhibitor, with Ki values of 9.36 and 13.1 nM for chymotrypsin and chymase, respectively.

Carboxymethyl cellulose sodium

Carboxymethyl cellulose sodium is frequently used as viscous agent, paste and barrier agent.

Ceruletide

Ceruletide is a biologically active decapeptide isolated from the skin of the Australian frog Hyla caerulea, acts as a cholecystokinin receptor agonist.

Gibberellin

Gibberellic acid (Gibberellin) is a plant hormone stimulating plant growth and development.

25-Hydroxycholesterol

25-Hydroxycholesterol (a metabolite of cholesterol) is a potent and selective suppressor of IgA production by B cells (EC50≈65 nM).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SBI-0640756, SBI-756 supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.