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Saquinavir

Cat. No. M5948

Saquinavir   Structure
Size Price Availability Quantity
10mg USD 60 In stock
50mg USD 250 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Saquinavir(Ro 31-8959) is an HIV Protease inhibitor used in antiretroviral therapy.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 670.84
Formula C38H50N6O5
CAS Number 127779-20-8
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Effect of a modified saquinavir/ritonavir dosing regimen with lower dose lead-in phase on QTc interval, pharmacokinetics, antiviral activity and safety in treatment-naïve HIV-1-infected patients.
Boffito M, et al. Drugs R D. 2015 Mar;15(1):141-53. PMID: 25742730.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Saquinavir supplier, HIV Protease, inhibitors

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