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S 25585 is a potent neuropeptide Y (NPY) Y5 receptor antagonist (IC50 values are 5.4, > 1000, > 10 000 and > 10 000 nM at Y5, Y1, Y2 and Y4 receptors respectively) that displays no affinity for a wide range of other receptors. Does not produce a conditioned taste aversion, suppress sodium appetite or cause pica in rats. Significantly inhibits NPY-induced feeding but not through blockade of Y5 receptors.
| Molecular Weight | 528.5 |
| Formula | C22H23F3N4O6S |
| CAS Number | 263849-50-9 |
| Solubility (25°C) | DMSO 52.85 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Awouters, et al. Annu Rev Pharmacol Toxicol. Pharmacology of antidiarrheal drugs.
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