Rosiridin inhibits MAO A and MAO B and has A potential role in depression and alzheimer's disease. The inhibition rate of Rosiridin against MAO B at 10 μM was 83.8% (pIC50=5.38).
| Molecular Weight | 332.39 |
| Formula | C16H28O7 |
| CAS Number | 100462-37-1 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Yurdanur Akgul, et al. Lotaustralin from Rhodiola rosea roots
| Related Monoamine Oxidase Products |
|---|
| Indazole
Indazole, also called isoindazole, a heterocyclic aromatic organic compound. |
| PF9601N
PF9601N is a monoamine oxidase B (MAO-B) inhibitor with neuroprotective properties in various ex vivo and in vivo models of Parkinson's disease (PD) for the study of excitotoxicity-mediated neurodegenerative diseases. In addition, PF9601N is a click chemistry reagent containing an Alkyne moiety that undergoes a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an Azide moiety. |
| Verbasoside
Decaffeoylacteoside is an inhibitor of AChE/BChE/LOX with moderate activity. |
| ETAP
ETAP is a MAO-A and MAO-B inhibitor. |
| Rosmarinic acid racemate
Rosmarinic acid racemate is the racemate of Rosmarinic acid. |
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