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Ropivacaine hydrochloride monohydrate

Cat. No. M2989
Ropivacaine hydrochloride monohydrate Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 38  USD38 In stock
50mg USD 86  USD86 In stock
100mg USD 136  USD136 In stock
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Quality Control & Documentation
Biological Activity

Ropivacaine hydrochloride monohydrate is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane.

Epidural administration of Ropivacaine hydrochloride monohydrate effectively blocks neuropathic pain (both mechanical allodynia and heat hyperalgesia) without induction of analgesic tolerance and significantly delays the development of neuropathic pain produced by peripheral nerve injury.

Ropivacaine hydrochloride monohydrate inhibits pressure-induced increases in filtration coefficient (Kf) without affecting pulmonary artery pressure (Ppa), pulmonary capillary pressures (Ppc), and zonal characteristics (ZC).

Ropivacaine hydrochloride monohydrate prevents pressure-induced lung edema and associated hyperpermeability as evidence by maintaining PaO2, lung wet-to-dry ratio and plasma volume in levels similar to sham rats.

Customer Product Validations & Biological Datas
Source Bioanalysis (2014). Figure 2. Ropivacaine hydrochloride
Method cell culture
Cell Lines primary murine skeletal muscle cells
Concentrations 1.7 mM, 3.3 mM, 5.8 mM, 8.3 mM, 16.5 mM
Incubation Time 24 h
Results Treatment of myocytes with bupivacaine and ropivacaine in vitro leads to cell destruction in a doseand drug-dependent manner.
Protocol (for reference only)
Cell Experiment
Cell lines C2C12 cell
Preparation method The other part was treated with ropivacaine hydrochloride in the same concentrations (1.7 mM, 3.3 mM, 5.8 mM, 8.3 mM, 16.5 mM, respectively). After incubation for 1 and 2 hours, the LA was removed.
Concentrations 1.7 mM, 3.3 mM, 5.8 mM, 8.3 mM, 16.5 mM
Incubation time 1 or 2 h
Animal Experiment
Animal models Sprague-Dawley rats
Formulation
Dosages 0.12 ml/kg
Administration i.v.
Chemical Information
Molecular Weight 328.88
Formula C17H28N2O2.HCl
CAS Number 132112-35-7
Solubility (25°C) DMSO 68 mg/mL
Water 40 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hofmann P, et al. Anesth Analg. The myotoxic effect of bupivacaine and ropivacaine on myotubes in primary mouse cell culture and an immortalized cell line.

[2] Sun Z, et al. Mol Med Rep. In vivo and in vitro evidence of the neurotoxic effects of ropivacaine: the role of the Akt signaling pathway.

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