RNase A, bovine pancreas cleaves RNA 3' to pyrimidines and cleaves RNA at each pyrimidine residue.Ribonuclease A catalyzes the hydrolysis of single-stranded RNA in the absence of metal ions or cofactors.
| CAS Number | 9001-99-4 |
| Form | Solid |
| Solubility (25°C) | Water 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Nucleic Acid Extraction and Purification Products |
|---|
| RNase Inhibitor, Murine
RNase Inhibitor, Murine specifically inhibits RNases A, B and C, thereby protecting RNA from degradation by these enzymes. |
| Universal nuclease |
| Recombinant DNase I (RNase Free) |
| Recombinant RNase R
Recombinant RNase R (E. coli) is a magnesium-dependent 3′→5′ exoribonuclease that can digest all linear RNAs but does not digest lariat or circular RNA structures. Most cellular RNAs will be digested completely by RNase R, with the exception of tRNAs, 5S RNA and intron lariats. |
| Recombinant RNase Inhibitor
RNase Inhibitor is a recombinant protein of murine origin expressed in E.coli, which specifically inhibits RNase A, B and C by binding noncovalently in a 1:1 ratio with high affinity. |
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