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Ritonavir

Cat. No. M2159
Ritonavir Structure
Synonym:

ABT-538

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 24  USD30 In stock
10mg USD 36  USD45 In stock
50mg USD 88  USD110 In stock
100mg USD 144  USD180 In stock
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Quality Control
Biological Activity

Ritonavir is an HIV protease inhibitor used in the study of HIV infection and AIDS.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 720.94
Formula C37H48N6O5S2
CAS Number 155213-67-5
Purity >99%
Solubility DMSO 20 mg/mL
Storage at -20°C
References

[1] Zeldin RK, et al. J Antimicrob Chemother. Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients.

[2] Morissette SL, et al. Proc Natl Acad Sci U S A. Elucidation of crystal form diversity of the HIV protease inhibitor ritonavir by high-throughput crystallization.

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Keywords: Ritonavir, ABT-538 supplier, HIV Protease, inhibitors

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