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Revaprazan

Cat. No. M29085
Revaprazan Structure
Synonym:

SB 641257

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Biological Activity

Revaprazan (SB 641257) is a reversible proton pump inhibitor with significant anti-inflammatory effects. Revaprazan can be used for chronic gastric inflammation research.

Chemical Information
Molecular Weight 362.44
Formula C22H23FN4
CAS Number 199463-33-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jung Sunwoo, et al. Aliment Pharmacol Ther. Pharmacodynamics of tegoprazan and revaprazan after single and multiple oral doses in healthy subjects

[2] Young-Min Han, et al. Biochem Pharmacol. Revaprazan prevented indomethacin-induced intestinal damages by enhancing tight junction related mechanisms

[3] Jong Hyuck Park, et al. Pharm Dev Technol. Revaprazan-loaded surface-modified solid dispersion: physicochemical characterization and in vivo evaluation

[4] Jung Suk Kim, et al. J Microencapsul. Novel revaprazan-loaded gelatin microsphere with enhanced drug solubility and oral bioavailability

[5] Kentaro Sugano. Therap Adv Gastroenterol. Vonoprazan fumarate, a novel potassium-competitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date

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Keywords: Revaprazan, SB 641257 supplier, Proton Pump, inhibitors, activators

 
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