Renin substrate 1 is a renin substrate with high affinity to the enzyme.
| Molecular Weight | 2282.67 |
| Formula | C109H156N32O21S |
| CAS Number | 791068-69-4 |
| Solubility (25°C) | Water |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Renin Products |
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| Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC
Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC (Renin Substrate I) is a renin substrate. |
| Renin inhibitor peptide, rat
Renin inhibitor peptide,rat is a biological active peptide. |
| Handle region peptide, rat
Handle region peptide, rat is a prorenin receptor antagonist, suppresses the progression of diabetic nephropathy and has anti-inflammatory in the eye. |
| SR 42128
SR 42128 is a potent renin inhibitor. |
| Terlakiren
Terlakiren (CP-80,794) is an orally active inhibitor of renin. |
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