Expression host: HEK293 cells
Molecular weight: the predicted molecular weight is 12.8 kD
Purity: >95% Analysis was performed by SDS-PAGE gel and HIGH performance liquid chromatography
Endotoxin: <0.1EU/μg (gel method)
Storage and stability: storage temperature: 2-8℃, lyophilized preparation can be stored at 2-8℃ for 24 months. If it is needed to be packaged separately, it can be dissolved with water for injection, normal saline, medium or PBS. After dissolved, it can be packaged separately into small portions and stored at -20℃ for 6 months and -80℃ for 12 months to avoid repeated freeze-thaw.
Bioactivity: Cell proliferation was measured with MO7e human megakaryocytic leukemia cells with an ED50 of 7-28 ng/mL
| Storage | 2-8℃ |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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