Recombinant Murine GM-CSF Protein is a hematopoietic growth factor that can promote the development of neutrophils and macrophages, and promote the proliferation and development of early erythroid megakaryocytes and eosinophilic progenitors. GM-CSF inhibits the migration of neutrophils and enhances the functional activity of mature terminal cells.
Depends on stimulating mouse FDC-P1 cell proliferation in a dose-dependent manner, the expected ED50 is ≤0.05 ng/ml, corresponding to specific activity ≥2×107 IU/mg.
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS at 100 μg/ml |
| Storage | Stored at ≤ -20°C, stable for one year after receipt |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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