Matrix metalloproteinase-12 (MMP12) contains 4 hemopexin repeats and belongs to the peptidase M10A family. MMP12 may be involved in tissue injury and remodeling and have significant elastolytic activity.
Recombinant Mouse Matrix Metalloproteinase 12 (MMP12) expressed the target gene encoding Ala29-Cys473 with a 6His tag at the C-terminus. The proenzyme needs to be activated by APMA for an activated form.
Accession: P34960
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 64 KDa, reducing conditions
Supplied as a 0.2 μm filtered solution of 20mM PB, 500mM NaCl, 0.01%Tween80, 1mM EDTA, 50% Glycerol, pH6.0.
The product is shipped on dry ice. Upon receipt, store it immediately at the temperature listed below.
Form | Solution |
Storage | Store at ≤ -70°C, stable for 6 months after receipt. |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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