Recombinant Mouse IGF-I belongs to the IGF family of peptides, which also includes IGF-II and insulin. IGF-I executes its functions via signaling through transmembrane tyrosine receptors (IGF Receptors). ED50 < 10.0 ng/ml, measured by a cell proliferation assay using FDC-P1 cells, corresponding to a specific activity of > 1.0 × 105 units/mg.
Accession: # P05017
Apparent Molecular Weight: ~7.8 kDa, on SDS-PAGE under reducing conditions
ED50 < 10.0 ng/ml, measured by a cell proliferation assay using FDC-P1 cells, corresponding to a specific activity of > 1.0 × 105 units/mg.
Lyophilized after extensive dialysis against PBS.
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH₂O up to 100 μg/ml. |
| Storage | Stable for up to 6 months at lower than -70°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] C Warburton, et al. Receptor. Mouse models of IGF-I deficiency generated by gene targeting
[5] G L Wong, et al. J Bone Miner Res. IGF-I production by mouse osteoblasts
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