Free shipping on all orders over $ 500

Recombinant Human Transferrin (Mammalian, C-6His)

Cat. No. M21471
Recombinant Human Transferrin (Mammalian, C-6His) Structure
Synonym:

Serotransferrin; Transferrin; Beta-1 metal-binding globulin

Size Price Availability Quantity
10ug USD 128  USD128 In stock
50ug USD 265  USD265 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
  • Purity: >95%, Endotoxin<1 EU/µg
  • COA
  • MSDS
Biological Activity

Species: Human
Expression system: Mammalian
Endotoxin: LAL test measured less than 0.1 ng/µg (1eu /µg)
Molecular weight: 76.2 KDa
Storage and stability: The freeze-dried protein should be stored at ≤-20°C for one year after receiving. The recombinant protein solution can be stored at 2-8℃ for 2-7 days. The bisector of the recombinant sample was stable at ≤-20°C for 3 months.


Biological activity: Serum transferrin belongs to the transferrin family and contains two transferrin like domains. This protein is a secreted protein, expressed by the liver and secreted in the plasma. Transferrin is an iron-bound transporter that can bind two Fe3+ ions and bind to one anion. It is responsible for transporting iron from where it is absorbed and heme is degraded to where it is stored and used. Serum transferrin may also have a further role in stimulating cell proliferation.

Chemical Information
Solubility (25°C) It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] T V Bobik, et al. Bull Exp Biol Med. Production of Recombinant Human Transferrin in Eukaryotic Pichia pastoris Expression System

[2] Martin E Brandsma, et al. Biotechnol Adv. Recombinant human transferrin: beyond iron binding and transport

[3] Deshui Zhang, et al. Protein Expr Purif. Expression, purification, and characterization of recombinant human transferrin from rice (Oryza sativa L.)

[4] Kimihiko Mizutani, et al. Biosci Biotechnol Biochem. Structural and functional characterization of recombinant human serum transferrin secreted from Pichia pastoris

[5] Peter J Sargent, et al. Biometals. Characterisation of recombinant unglycosylated human serum transferrin purified from Saccharomyces cerevisiae

Related Recombinant Proteins Products
Recombinant Human Tau-F Protein (E.coli)

Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity.

Recombinant Human Tau Protein (E. coli, His Tag)

Tau proteins are proteins that stabilize microtubules. Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are mostly found in neurons compared to non-neuronal cells. One of tau's main functions is to modulate the stability of axonal microtubules.

Recombinant Rat IL-23 Protein (HEK293, C-His)

IL-23 (IL-23 alpha & IL-12 beta Heterodimer) Protein is a recombinant protein dimer complex containing rat-derived IL-23 alpha & IL-12 beta Heterodimer protein, expressed by HEK293.

Recombinant Rat IL-6 (HEK293)

Interleukin-6 (IL-6), also known as BSF-2, CDF and IFNB2, is a pleiotropic cytokine that participates in both pro-inflammatory and anti-inflammatory responses.

Recombinant Rat IL-12 (Mammalian, C-6His)

Interleukin 12 (IL-12) has important immunological functions. IL12 facilitates hematopoietic stem cell proliferation, induces NK cell proliferation, and potentiates the expansion and late activation of Th1 CD4+ T cells.

  Catalog
Abmole Inhibitor Catalog




Keywords: Recombinant Human Transferrin (Mammalian, C-6His), Serotransferrin; Transferrin; Beta-1 metal-binding globulin supplier, Recombinant Proteins, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.